Home Antibody All anti-TMEM18 antibodies
Also for TMEM18 (NM_152834)
|TMEM18 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human TMEM18.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transmembrane protein 18 (TMEM18)|
Entrez Gene 129787 Human
Entrez Gene 211986 Mouse
Entrez Gene 362722 Rat
|Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.|
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Western blot analysis of TMEM18 in rat brain lysate with TMEM18 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of TMEM18 in mouse brain tissue with TMEM18 antibody at 2.5 ug/mL.