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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306728
  • Chicken Polyclonal CDKN2A Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400022) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCDKN2A antibody was raised against an 18 amino acid peptide from near the amino terminus of human CDKN2A.
Clone Name IsotypeIgY
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
FunctionThe CDKN2A locus gives rise to 2 distinct transcripts from different promoters. The transcripts have been designated p16(INK4A) and p14(ARF). This chromosomal region undergoes a number of inversions, translocations, heterozygous deletions, and homozygous deletions in a variety of malignant cell lines including those from glioma, non-small cell lung cancer, leukemia, and melanoma. Deletion of the region containing CDKN2A is found in more than half of all melanoma cell lines. Conversely, transfection of CDKN2A suppressed the growth of two independent mesothelioma cell lines, suggesting that inactivation of the CDKN2 gene is an essential step in the etiology of malignant mesotheliomas. CDKN2A induces a G1 cell cycle arrest by inhibiting the phosphorylation of the Rb protein by the cyclin-dependent kinases CDK4 and CDK6. CDKN2A is expressed as at least three distinct isoforms.
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

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WB Image
Western blot analysis of CDKN2A in C2C12 cell lysate with CDKN2A antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of CDKN2A in human colon tissue with CDKN2A antibody at 20 ug/mL.

 

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