Home Antibody All anti-ATG5 antibodies
Also for ATG5 (NM_004849)
|ATG5 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ATG5.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens autophagy related 5 (ATG5), transcript variant 1|
|APG5; APG5-LIKE; APG5L; ASP; hAPG5|
|Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.|
Senescence and Autophagy
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Western blot analysis of ATG5 in mouse spleen tissue lysate with ATG5 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of ATG5 in human spleen tissue with ATG5 antibody at 2.5 ug/ml.