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Home Antibody All anti-KLRA1 antibodies

Anti-KLRA1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306715
  • Rabbit Polyclonal KLRA1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC416527) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for KLRA1 (NM_006611)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenKLRA1 antibody was raised against a 13 amino acid peptide near the center of human KLRA1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 2 ug/ml, ICC: 4 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens killer cell lectin-like receptor subfamily A, member 1 (KLRA1)
Alternative NameKLRA#; Ly-49L; Ly49; LY49L; MGC126520; MGC126522;class I MHC receptor KLRA22; Klra22; A1; Ly49a; Ly49o; Ly49v; OTTMUSP00000026268; natural killer cell receptor Ly49A; killer cell lectin-like receptor, subfamily A, member 1
Database LinkNP_006602
FunctionKLRA1 (also known as Ly49L) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. At least three isoforms of KLRA1 are known to exist; this antibody recognizes only the long isoform.
Related Pathway

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WB Image
Western blot analysis of KLRA1 in mouse spleen tissue lysate with KLRA1 antibody at (A) 1 ug/mL and (B) 2 ug/mL.
IF Image
Immunocytochemistry of KLRA1 in 293 cells with KLRA1 antibody at 4 ug/mL.

 

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