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Home Antibody All anti-RNASEH2A antibodies

Anti-RNASEH2A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306706
  • Rabbit Polyclonal RNAse H2A Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416666) , 20ug Explanation
100ug 325 3 Weeks
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WB(1)
IF(1)
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Also for RNASEH2A (NM_006397)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRNAse H2A antibody was raised against a 17 amino acid peptide near the center of human RNAse H2A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 2 ug/ml, IF: 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ribonuclease H2, subunit A (RNASEH2A)
Alternative NameAGS4; JUNB; RNASEHI; RNHIA; RNHL
Database LinkNP_006388
Entrez Gene 10535 Human
Entrez Gene 69724 Mouse
Entrez Gene 364974 Rat
FunctionRibonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
Related Pathway DNA replication

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RNAse H2A in HeLa cell lysate with RNAse H2A antibody at 1 ug/mL.
IF Image
Immunocytochemistry of RNAse H2A in HeLa cells with RNAse H2A antibody at 2 ug/mL.

 

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