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Home Antibody All anti-GLE1 antibodies

Anti-GLE1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306704
  • Rabbit Polyclonal Gle1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423996) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for GLE1 (NM_001003722)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenGle1 antibody was raised against a 14 amino acid peptide near the center of human Gle1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens GLE1 RNA export mediator (GLE1), transcript variant 1
Alternative NameGLE1L; hGLE1; LCCS; LCCS1
Database LinkNP_001003722
FunctionThe proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.
Related Pathway

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WB Image
Western blot analysis of Gle1 in 293 cell lysate with Gle1 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of Gle1 in mouse brain tissue with Gle1 antibody at 2.5 ug/ml.

 

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