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Home Antibody All anti-TREX1 antibodies

Anti-TREX1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306702
  • Rabbit Polyclonal TREX1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402546) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenTREX1 antibody was raised against a 15 amino acid peptide near the center of human TREX1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens three prime repair exonuclease 1 (TREX1), transcript variant 1
Alternative NameAGS1; CRV; DRN3; HERNS
Database LinkNP_057465
FunctionTrex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. TREX1 antibody will not cross-react with the related protein TREX2.
Related Pathway

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WB Image
Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of TREX1 in human spleen tissue with TREX1 antibody at 2.5 ug/ml.

 

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