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Home Antibody All anti-LASS5 antibodies

Anti-LASS5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306688
  • Rabbit Polyclonal LASS5 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenLASS5 antibody was raised against a 14 amino acid peptide near the amino terminus of the human LASS5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ceramide synthase 5 (CERS5), transcript variant 1
Alternative NameLASS5; Trh4
Database LinkNP_671723
FunctionThe LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis. Multiple isoforms of LASS5 are known to exist. This antibody is predicted not to cross-react with the highly homologous LASS6.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of LASS5 in SK-N-SH lysate with LASS5 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of LASS5 in mouse brain tissue with LASS5 antibody at 2.5 ug/ml.

 

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