Home Antibody All anti-IL17A antibodies
Also for IL17A (NM_002190)
|IL-17 antibody was raised against a 19 amino acid peptide from near the center of human IL-17A.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 17A (IL17A)|
|CTLA8; IL-17; IL-17A; IL17|
Entrez Gene 3605 Human
Entrez Gene 16171 Mouse
|Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-kB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.|
|Secreted ProteinDruggable Genome Cytokine-cytokine receptor interaction|
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Western blot analysis of IL-17 in A-20 lysate with IL-17 antibody at (A) 0.5 and (B) 1 µg/ml.