Home Antibody All anti-DACT2 antibodies
Also for DACT2 (NM_214462)
|Dact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens dishevelled-binding antagonist of beta-catenin 2 (DACT2), transcript variant 1|
|bA503C24.7; C6orf116; DAPPER2; DPR2|
|The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.|
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Western blot analysis of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 ug/ml.
Immunohistochemistry of Dact2 in human brain tissue with Dact2 antibody at 2.5 ug/ml.