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Home Antibody All anti-DACT2 antibodies

Anti-DACT2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306668
  • Rabbit Polyclonal Dact2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403742) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenDact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens dishevelled-binding antagonist of beta-catenin 2 (DACT2), transcript variant 1
Alternative NamebA503C24.7; C6orf116; DAPPER2; DPR2
Database LinkNP_999627
FunctionThe Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of Dact2 in human brain tissue with Dact2 antibody at 2.5 ug/ml.

 

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