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Anti-DACT2 Antibody


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306668 Rabbit Polyclonal Dact2 Antibody 100ug $325 2 Weeks
LC403742 DACT2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenDact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens dishevelled-binding antagonist of beta-catenin 2 (DACT2), transcript variant 1
Alternative NamebA503C24.7; C6orf116; DAPPER2; DPR2
Database LinkNP_999627
Entrez Gene 168002 Human
Entrez Gene 240025 Mouse
Entrez Gene 308212 Rat
FunctionThe Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 ug/ml.
Immunohistochemistry of Dact2 in human brain tissue with Dact2 antibody at 2.5 ug/ml.


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