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Anti-AIPL1 Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	Aipl1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human Aipl1.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse	Concentration	1ug/ul
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1 - 2 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), transcript variant 2
Alternative Name	AIPL2; LCA4
Database Link	NP_001028226
Function	Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
Related Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • AIPL1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • AIPL1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Aipl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • AIPL1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Aipl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), transcript variant 2 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), transcript variant 2 as transfection-ready DNA Related cDNA Clones • Homo sapiens aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), transcript variant 2 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)