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Home Antibody All anti-CUEDC2 antibodies

Anti-CUEDC2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306660
  • Rabbit Polyclonal CUEDC2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411416) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for CUEDC2 (NM_024040)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCUEDC2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CUEDC2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens CUE domain containing 2 (CUEDC2)
Alternative NamebA18I14.5; C10orf66
Database LinkNP_076945
Entrez Gene 79004 Human
Entrez Gene 67116 Mouse
Entrez Gene 294009 Rat
FunctionThe CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-a and IKK-b and decrease the activation of NF-kB by decreasing the activation of IKK. CUEDC2 antibody will not cross-react with CUEDC1.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CUEDC2 in HeLa cell lysate with CUEDC2 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunocytochemistry of CUEDC2 in HeLa cells with CUEDC2 antibody at 5 ug/mL.

 

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