Home Antibody All anti-CUEDC2 antibodies
Also for CUEDC2 (NM_024040)
|CUEDC2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CUEDC2.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens CUE domain containing 2 (CUEDC2)|
Entrez Gene 79004 Human
Entrez Gene 67116 Mouse
Entrez Gene 294009 Rat
|The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-a and IKK-b and decrease the activation of NF-kB by decreasing the activation of IKK. CUEDC2 antibody will not cross-react with CUEDC1.|
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Western blot analysis of CUEDC2 in HeLa cell lysate with CUEDC2 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of CUEDC2 in HeLa cells with CUEDC2 antibody at 5 ug/mL.