Home Antibody All anti-OTUD5 antibodies
Also for OTUD5 (NM_001136157)
|OTUD5 antibody was raised against a 13 amino acid peptide near the carboxy terminus of the human OTUD5.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens OTU deubiquitinase 5 (OTUD5), transcript variant 2|
Entrez Gene 55593 Human
Entrez Gene 54644 Mouse
Entrez Gene 363452 Rat
|OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.|
|Protease RIG-I-like receptor signaling pathway|
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Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 ug/ml.