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Home Antibody All anti-OTUD5 antibodies

Anti-OTUD5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306650
  • Rabbit Polyclonal OTUD5 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC427830) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for OTUD5 (NM_001136157)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenOTUD5 antibody was raised against a 13 amino acid peptide near the carboxy terminus of the human OTUD5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens OTU deubiquitinase 5 (OTUD5), transcript variant 2
Alternative NameDUBA
Database LinkNP_001129629
FunctionOTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.
Related Pathway

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WB Image
Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 ug/ml.

 

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