Home Antibody All anti-S1PR1 antibodies
Also for S1PR1 (NM_001400)
|S1P1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human S1P1.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens sphingosine-1-phosphate receptor 1 (S1PR1)|
|CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1|
|Movement of lymphocytes through lymphoid organs is required for generating immunity. Their migration into lymph nodes follows a series of events including integrin activation through chemokine signaling, adhesion and diapedis. The release of lymphocytes from lymph nodes is regulated by the phospholipid sphingosine-1-phosphate (S1P). One of its receptors S1P1 binds S1P with high specificity and affinity; agonism of this receptor by the immunosuppressive agent FTY720 inhibits the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions. Recent experiments have indicated that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did and these cells where also less effectively retained after treatment with FTY720, and that egress competence could be restored by inactivating G alpha i-protein-coupled receptor signaling. These results suggest that S1P1 acts in the lymphocyte to promote lymph node egress by overcoming retention signals mediated by CCR7 and G alpha i-protein-coupled receptor signaling. At least two isoforms of S1P1 are known to exist; this S1P1 antibody will only recognize the shorter isoform.|
Signaling by GPCR
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Western blot analysis of S1P1 in mouse thymus lysate with S1P1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of S1P1 in mouse thymus tissue with S1P1 antibody at 5 ug/ml.