Home Antibody All anti-ALDH5A1 antibodies
Also for ALDH5A1 (NM_001080)
|Aldh5A1 antibody was raised against a 22 amino acid peptide near the carboxy terminus of the human Aldh5A1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens aldehyde dehydrogenase 5 family, member A1 (ALDH5A1), transcript variant 2|
Entrez Gene 7915 Human
Entrez Gene 214579 Mouse
Entrez Gene 291133 Rat
|Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.|
|Druggable Genome Alanine, aspartate and glutamate metabolismButanoate metabolismMetabolic pathways|
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Western blot analysis of Aldh5A1 in mouse liver lysate with Aldh5A1 antibody at (A) 1 and (B) 2 µg/ml.