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Home Antibody All anti-ACVR1 antibodies

Anti-ACVR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306641
  • Rabbit Polyclonal ACVR1B Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC420209) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for ACVR1 (NM_001105)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenACVR1B antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human ACVR1B.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens activin A receptor, type I (ACVR1), transcript variant 1
Alternative NameACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Database LinkNP_001096
FunctionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions. At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
Related Pathway
Cytokine-cytokine receptor interaction
TGF Beta Signaling Pathway

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WB Image
Western blot analysis of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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