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Home Antibody All anti-ACVR1 antibodies

Anti-ACVR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306640
  • Rabbit Polyclonal ACVR1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420209) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for ACVR1 (NM_001105)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenACVR1 antibody was raised against a 14 amino acid peptide near the amino terminus of the human ACVR1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens activin A receptor, type I (ACVR1), transcript variant 1
Alternative NameACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Database LinkNP_001096
Entrez Gene 90 Human
Entrez Gene 11477 Mouse
FunctionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients. At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1B or ACVR1C.
Related PathwayProtein KinaseES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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