Home Antibody All anti-Trim30 antibodies
Also for Trim30 (XM_907934)
|TRIM30 antibody was raised against a 24 amino acid peptide near the amino terminus of the mouse TRIM30.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|PREDICTED: Mus musculus tripartite motif-containing 30-2 (Trim30-2)|
Entrez Gene 434219 Mouse
Entrez Gene 502360 Rat
|TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NFkappa-B activation. The importance of TRIM30 in the attenuation or termination of NFkappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30 alpha may be a mechanism for modulating many types of immune responses.|
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Western blot analysis of TRIM30 in mouse heart tissue lysate with TRIM30 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of TRIM30 in mouse ovary tissue with TRIM30 antibody at 10 ug/ml.