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Home Antibody All anti-NANOS2 antibodies

Anti-NANOS2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306593
  • Rabbit Polyclonal Nanos2 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NANOS2 (NM_001029861)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNanos2 antibody was raised against a 13 amino acid peptide near the amino terminus of the human Nanos2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nanos homolog 2 (Drosophila) (NANOS2)
Alternative NameNOS2
Database LinkNP_001025032
Entrez Gene 339345 Human
Entrez Gene 378430 Mouse
Entrez Gene 365213 Rat
FunctionNanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects. This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Nanos2 in rat brain tissue lysate with Nanos2 antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of Nanos2 in human brain tissue cells with Nanos2 antibody at 2.5 ug/ml.

 

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