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Home Antibody All anti-RIMS2 antibodies

Anti-RIMS2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306577
  • Rabbit Polyclonal Rim2 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenRim2 antibody was raised against a 17 amino acid peptide near the center of the human Rim2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant 1
Alternative NameOBOE; RAB3IP3; RIM2
Database LinkNP_001093587
FunctionRab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. Rim2 is known to exist in multiple isoforms; this antibody should recognize most of them. This antibody is predicted to have no cross-reactivity to other Rim proteins.
Related Pathway

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WB Image
Western blot analysis of Rim2 in rat brain tissue lysate with Rim2 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.
IHC Image
Immunohistochemistry of Rim2 in human brain with Rim2 antibody at 5 ug/ml.

 

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