Home Antibody All anti-TNPO3 antibodies
Also for TNPO3 (NM_012470)
|TNPO3 antibody was raised against a 18 amino acid peptide from near the amino terminus of human TNPO3.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens transportin 3 (TNPO3), transcript variant 1|
|IPO12; MTR10A; TRN-SR; TRN-SR2; TRNSR|
|TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.|
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Western blot analysis of TNPO3 in Raji cell lysate with TNPO3 antibody at (A) 1 and (B) 2 µg/ml.