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Home Antibody All anti-VPS53 antibodies

Anti-VPS53 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306570
  • Rabbit Polyclonal VPS53 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC426901) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for VPS53 (NM_001128159)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenVPS53 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human VPS53.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 1 ug/ml, ICC: 5 ug/ml, IF: 2.5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens vacuolar protein sorting 53 homolog (S. cerevisiae) (VPS53), transcript variant 1
Alternative NameHCCS1; hVps53L; pp13624
Database LinkNP_001121631
FunctionThe sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
Related Pathway

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WB Image
Western blot analysis of VPS53 in 293 cell lysate with VPS53 antibody at (A) 0.5 and (B) 1 ug/mL.
IF Image
Immunocytochemistry of VPS53 in 293 cells with VPS53 antibody at 5 ug/mL.

 

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