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Home Antibody All anti-IRGM antibodies

Anti-IRGM Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306552
  • Rabbit Polyclonal IRGM Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC429013) , 20ug
100ug $325 3-7 Days
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WB(1)
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Also for IRGM (NM_001145805)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenIRGM antibody was raised against a 17 amino acid peptide near the amino terminus of the human IRGM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens immunity-related GTPase family, M (IRGM)
Alternative NameIFI1; IRGM1; LRG-47; LRG47
Database LinkNP_001139277
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn’s disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.
Related Pathway

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WB Image
Western blot analysis of IRGM in Rat brain lysate with IRGM antibody at (A) 1 and (B) 2 µg/ml.

 

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