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Home Antibody All anti-AIFM3 antibodies

Anti-AIFM3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306550
  • Rabbit Polyclonal AIFM3 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422714) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for AIFM3 (NM_001018060)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenAIFM3 antibody was raised against a 16 amino acid peptide from near the amino terminus of human AIFM3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 and 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3), transcript variant 2
Alternative NameAIFL
Database LinkNP_001018070
FunctionApoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
Related Pathway

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WB Image
Western blot analysis of NIPSNAP in human brain tissue lysate with NIPSNAP antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemical staining of human brain tissue using AIFM3 antibody at 2.5 ug/ml.

 

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