RTP801 antibody was raised against a 14 amino acid peptide from near the amino terminus of human RTP801.
Buffer
PBS containing 0.02% sodium azide.
Clone Name
Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Concentration
1ug/ul
Purification
Affinity chromatography purified via peptide column
Guaranteed Application *
WB
Suggested Dilutions
RTP801 antibody can be used for the detection of RTP801 by Western blot at 2 – 4 µg/ml.
Background
RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Related Pathway
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