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Also for RIMS3 (NM_014747)
|Rim3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Rim3.|
||WB: 0. 5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens regulating synaptic membrane exocytosis 3 (RIMS3)|
|Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity. This antibody is predicted to have no cross-reactivity to other Rim proteins.|
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Western blot analysis of Rim3 in human brain tissue lysate with Rim3 antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Immunohistochemistry of Rim3 in human brain tissue with Rim3 antibody at 2.5 ug/ml.