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Home Antibody All anti-ATG5 antibodies

Anti-ATG5 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306517 Rabbit Polyclonal ATG5 Antibody 100ug $325 3 Weeks
LC401532 ATG5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenATG5 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ATG5.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens autophagy related 5 (ATG5), transcript variant 1
Alternative NameAPG5; APG5-LIKE; APG5L; ASP; hAPG5
Database LinkNP_004840
Entrez Gene 9474 Human
Entrez Gene 11793 Mouse
Entrez Gene 365601 Rat
FunctionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.
Related PathwayDruggable Genome Regulation of autophagyRIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of ATG5 in rat spleen tissue lysate with ATG5 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of ATG5 in human spleen tissue with ATG5 antibody at 2.5 ug/ml.


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