Home Antibody All anti-GSTP1 antibodies
Also for GSTP1 (NM_000852)
|GSTP1 antibody was raised against a 14 amino acid peptide from near the center of human GSTP1.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens glutathione S-transferase pi 1 (GSTP1)|
|DFN7; FAEES3; GST3; GSTP; HEL-S-22; PI|
Entrez Gene 2950 Human
Entrez Gene 14870 Mouse
Entrez Gene 24426 Rat
|Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer. More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson’s disease. CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer.|
|Druggable Genome Glutathione metabolismMetabolism of xenobiotics by cytochrome P450Drug metabolism - cytochrome P450Pathways in cancerProstate cancer|
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Western blot analysis of GSTP1 in Jurkat cell lysate with GSTP1 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemical staining of human lung tissue using GSTP1 antibody at 2.5 ug/ml.