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Home Antibody All anti-FNBP1L antibodies

Anti-FNBP1L Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306490
  • Rabbit Polyclonal TOCA-1 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for FNBP1L (NM_001024948)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenTOCA-1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human TOCA-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens formin binding protein 1-like (FNBP1L), transcript variant 1
Alternative NameC1orf39; TOCA1
Database LinkNP_001020119
FunctionActin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.
Related Pathway

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WB Image
Western blot analysis of TOCA-1 in mouse brain tissue lysate with in (A) the absence and (B) the presence of blocking peptide with TOCA-1 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of TOCA-1 in human brain tissue with TOCA-1 antibody at 2.5 ug/ml.

 

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