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Home Antibody All anti-ARMET antibodies

Anti-ARMET Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306478
  • Rabbit Polyclonal MANF Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401818) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ARMET (NM_006010)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMANF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human MANF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mesencephalic astrocyte-derived neurotrophic factor (MANF)
Alternative NameARMET; ARP
Database LinkNP_006001
FunctionMANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson’s disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress. This antibody does not cross-react with CDNF.
Related Pathway

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WB Image
Western blot analysis of MANF in mouse brain tissue lysate with MANF antibody at (A) 1 and (B) 2 ug/ml.
IHC Image
Immunohistochemistry of MANF in human brain tissue with MANF antibody at 2.5 ug/ml.

 

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