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Home Antibody All anti-MANF antibodies

Anti-MANF Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306478 Rabbit Polyclonal MANF Antibody 100ug $325 3-7 Days
LC401818 MANF HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenMANF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human MANF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target Namemesencephalic astrocyte derived neurotrophic factor
Alternative NameARMET|ARP
Database LinkNP_006001
Entrez Gene 7873 Human
Entrez Gene 74840 Mouse
Entrez Gene 315989 Rat
FunctionMANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson’s disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress. This antibody does not cross-react with CDNF.
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MANF in mouse brain tissue lysate with MANF antibody at (A) 1 and (B) 2 ug/ml.

IHC Image
Immunohistochemistry of MANF in human brain tissue with MANF antibody at 2.5 ug/ml.

IF Image
Immunofluorescence of MANF in Human Brain cells with MANF antibody at 20 ug/mL.


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