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Home Antibody All anti-BRCC3 antibodies

Anti-BRCC3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306473
  • Rabbit Polyclonal BRCC36 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422709) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BRCC3 (NM_001018055)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenBRCC36 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC36.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BRCA1/BRCA2-containing complex, subunit 3 (BRCC3), transcript variant 2
Alternative NameBRCC36; C6.1A; CXorf53
Database LinkNP_001018065
Entrez Gene 79184 Human
Entrez Gene 210766 Mouse
Entrez Gene 316794 Rat
FunctionTogether with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BRCC36 in MCF7 cell lysate with BRCC36 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of BRCC36 in human brain tissue with BRCC36 antibody at 2.5 ug/ml.

 

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