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Home Antibody All anti-TRIM25 antibodies

Anti-TRIM25 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306467
  • Rabbit Polyclonal TRIM25 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417532) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TRIM25 (NM_005082)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTRIM25 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TRIM25.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/ml, ICC: 20 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tripartite motif containing 25 (TRIM25)
Alternative NameEFP; RNF147; Z147; ZNF147
Database LinkNP_005073
Entrez Gene 7706 Human
Entrez Gene 217069 Mouse
FunctionTRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
Related PathwayTranscription FactorsDruggable Genome RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TRIM25 in HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with TRIM25 antibody at 1 ug/mL.
IF Image
Immunocytochemistry of TRIM25 in HeLa cells with TRIM25 antibody at 20 ug/mL.

 

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