Home Antibody All anti-PTK7 antibodies
Also for PTK7 (NM_002821)
|PTK7 antibody was raised against a 15 amino acid peptide from near the amino terminus of human PTK7.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens protein tyrosine kinase 7 (PTK7), transcript variant PTK7-1|
|Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.|
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Western blot analysis of PTK7 in (A) human, (B) mouse and (C) rat colon tissue lysate with PTK7 antibody at 1 ug/ml.
Immunohistochemistry of PTK7 in human colon tissue with PTK7 antibody at 5 ug/ml.