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Home Antibody All anti-TARDBP antibodies

Anti-TARDBP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306453
  • Rabbit Polyclonal TDP43 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402137) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TARDBP (NM_007375)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTDP43 antibody was raised against a 15 amino acid peptide from near the amino terminus of human TDP43.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TAR DNA binding protein (TARDBP)
Alternative NameALS10; TDP-43
Database LinkNP_031401
FunctionTDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3’ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences. At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TDP43 in HeLa cell lysate with TDP43 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
IF Image
Immunocytochemistry of TDP43 in HeLa cells with TDP43 antibody at 5 ug/mL.

 

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