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Home Antibody All anti-TBC1D10C antibodies

Anti-TBC1D10C Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306445 Rabbit Polyclonal Carabin Antibody 100ug $325 3-7 Days
LC404903 TBC1D10C HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for TBC1D10C (NM_198517)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenCarabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TBC1 domain family, member 10C (TBC1D10C), transcript variant 1
Alternative NameCARABIN; EPI64C
Database LinkNP_940919
Entrez Gene 374403 Human
Entrez Gene 108995 Mouse
FunctionAntigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Carabin in Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 ug/ml.


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