Home Antibody All anti-TBC1D1 antibodies
Also for TBC1D1 (NM_015173)
|TBC1D1 antibody was raised against a 22 amino acid peptide from near the carboxy terminus of human TBC1D1.|
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1), transcript variant 1|
Entrez Gene 23216 Human
|TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.|
|Druggable Genome |
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Western blot analysis of TBC1D1 in Daudi cell lysate with TBC1D1 antibody at (A) 1, (B) 2 and (C) 4 µg/ml.