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Home Antibody All anti-TBC1D1 antibodies

Anti-TBC1D1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306433
  • Rabbit Polyclonal TBC1D1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414764) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for TBC1D1 (NM_015173)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTBC1D1 antibody was raised against a 22 amino acid peptide from near the carboxy terminus of human TBC1D1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1), transcript variant 1
Alternative NameTBC; TBC1
Database LinkNP_055988
Entrez Gene 23216 Human
FunctionTBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TBC1D1 in Daudi cell lysate with TBC1D1 antibody at (A) 1, (B) 2 and (C) 4 µg/ml.

 

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