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Home Antibody All anti-BUB1 antibodies

Anti-BUB1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306432 Rabbit Polyclonal Bub1 Antibody 100ug $325 In Stock
LC401381 BUB1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenBub1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human Bub1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 - 4 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BUB1 mitotic checkpoint serine/threonine kinase (BUB1), transcript variant 1
Alternative NameBUB1A; BUB1L; hBUB1
Database LinkNP_004327
Entrez Gene 699 Human
Entrez Gene 12235 Mouse
FunctionBub1 was initially identified as the mammalian homolog to the yeast protein through a cDNA screen. Bub1 encodes a kinase involved in the formation of the spindle checkpoint, an important mechanism that ensures high fidelity mitotic chromosome segregation. It is thought to be required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshim protein and metaphase congression. Bub1 functions by phosphorylating cdc20, a member of the mitotic checkpoint complex and activating the spindle checkpoint. A related protein kinase Bub3 interacts with Bub1 and targets it to kinetochores prior to chromosome alignment. Mutations in bub1 have been associated with aneuploidy and several forms of cancer.
Related PathwayProtein KinaseDruggable Genome Cell cycleOocyte meiosisProgesterone-mediated oocyte maturation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of bub1 in A-20 lysate with bub1 antibody at (A) 2 and (B) 4 ug/mL.
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Immunocytochemistry of Bub1 in A20 cells with Bub1 antibody at 10 ug/mL.
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