Home Antibody All anti-PSEN1 antibodies
Also for PSEN1 (NM_000021)
|Presenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens presenilin 1 (PSEN1), transcript variant 1|
|AD3; FAD; PS-1; PS1; S182|
Entrez Gene 5663 Human
Entrez Gene 19164 Mouse
Entrez Gene 29192 Rat
|Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer’s disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.|
|TransmembraneProteaseDruggable Genome Wnt signaling pathwayNotch signaling pathwayNeurotrophin signaling pathwayAlzheimer's disease|
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Western blot analysis of presenilin1 in human brain lysate with presenilin1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of Presenilin1 in human brain tissue with Presenilin1 antibody at 2.5 ug/ml.