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Home Antibody All anti-PSEN1 antibodies

Anti-PSEN1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306424 Rabbit Polyclonal Presenilin1 Antibody 100ug $325 In Stock
LC424973 PSEN1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for PSEN1 (NM_000021)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenPresenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens presenilin 1 (PSEN1), transcript variant 1
Alternative NameAD3; FAD; PS-1; PS1; S182
Database LinkNP_000012
Entrez Gene 5663 Human
Entrez Gene 19164 Mouse
Entrez Gene 29192 Rat
FunctionPresenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer’s disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.
Related PathwayTransmembraneProteaseDruggable Genome Wnt signaling pathwayNotch signaling pathwayNeurotrophin signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of presenilin1 in human brain lysate with presenilin1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

IHC Image
Immunohistochemistry of Presenilin1 in human brain tissue with Presenilin1 antibody at 2.5 ug/ml.

IF Image
Immunofluorescence of Presenilin1 in Human Brain cells with Presenilin1 antibody at 20 ug/mL.


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