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Home Antibody All anti-PSEN1 antibodies

Anti-PSEN1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306424 Rabbit Polyclonal Presenilin1 Antibody 100ug $325 In Stock
LC424973 PSEN1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for PSEN1 (NM_000021)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenPresenilin1 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human presenilin1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens presenilin 1 (PSEN1), transcript variant 1
Alternative NameAD3; FAD; PS-1; PS1; S182
Database LinkNP_000012
Entrez Gene 5663 Human
Entrez Gene 19164 Mouse
Entrez Gene 29192 Rat
FunctionPresenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the g-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-a-converting enzyme (TACE) and the b-site cleavage enzyme (BACE) protease families, g-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the a and g cleavage site) or the toxic Ab amyloid peptide (from the b and g cleavage site). It is thought that accumulation of the Ab peptide is the precursor to Alzheimer’s disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.
Related PathwayTransmembraneProteaseDruggable Genome Wnt signaling pathwayNotch signaling pathwayNeurotrophin signaling pathwayAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of presenilin1 in human brain lysate with presenilin1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
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Immunohistochemistry of Presenilin1 in human brain tissue with Presenilin1 antibody at 2.5 ug/ml.
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