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Also for ORAI2 (NM_001126340)
|ORAI2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human ORAI2.|
||ELISA, WB: 1 - 4 ug/ml, ICC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens ORAI calcium release-activated calcium modulator 2 (ORAI2), transcript variant 1|
|C7orf19; CBCIP2; MEM142B; TMEM142B|
|Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3.|
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Western blot analysis of ORAI2 in Jurkat cell lysate with ORAI2 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.
Immunocytochemistry of ORAI2 in Jurkat cells with ORAI2 antibody at 5 ug/mL.