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Home Antibody All anti-CD82 antibodies

Anti-CD82 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306407
  • Rabbit Polyclonal KAI1 Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenKAI1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human KAI1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens CD82 molecule (CD82), transcript variant 2
Alternative Name4F9; C33; GR15; IA4; KAI1; R2; SAR2; ST6; TSPAN27
Database LinkNP_001020015
Entrez Gene 3732 Human
Entrez Gene 12521 Mouse
Entrez Gene 83628 Rat
FunctionKAI1 was initially identified from a T-cell activation study as a four-transmembrane protein that plays an accessory role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is ubiquitously expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. Recently, KAI1 was found to interact with DARC, the Duffy antigen for chemokines using a yeast two hybrid screen. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least two isoforms of KAI1 are known to exist.
Related PathwayTransmembraneDruggable Genome p53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of KAI1 in A549 cell lysate with KAI1 antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of KAI1 in human colon tissue with KAI1 antibody at 2.5 ug/ml.

 

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