Home Antibody All anti-MAVS antibodies
Also for MAVS (NM_020746)
|VISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens mitochondrial antiviral signaling protein (MAVS), transcript variant 1|
|CARDIF; IPS-1; IPS1; VISA|
Entrez Gene 57506 Human
Entrez Gene 228607 Mouse
Entrez Gene 311430 Rat
|Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.|
|Transmembrane RIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Western blot analysis of VISA in rat brain tissue lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of VISA in mouse brain tissue with VISA antibody at 2.5 ug/ml.