Home Antibody All anti-IFIH1 antibodies
Also for IFIH1 (NM_022168)
|MDA5 antibody was raised against a 16 amino acid peptide from near the center of human MDA5.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interferon induced with helicase C domain 1 (IFIH1)|
|AGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2|
Entrez Gene 64135 Human
Entrez Gene 71586 Mouse
|The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.|
| RIG-I-like receptor signaling pathway|
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Western blot analysis of MDA5 in Daudi cell lysate with MDA5 antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
Immunohistochemistry of MDA5 in human lymph node tissue with MDA5 antibody at 5 ug/ml.