Home Antibody All anti-DRAM antibodies
Also for DRAM (NM_018370)
|DRAM antibody was raised against a 16 amino acid peptide from near the amino terminus of human DRAM.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens DNA-damage regulated autophagy modulator 1 (DRAM1)|
Entrez Gene 55332 Human
Entrez Gene 71712 Mouse
Entrez Gene 679937 Rat
|Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.|
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Western blot analysis of DRAM in K562 cell lysate with DRAM antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of DRAM in human liver tissue with DRAM antibody at 2.5 ug/ml.