Home Antibody All anti-EMD antibodies
|Emerin antibody was raised against a 19 amino acid peptide from near the amino terminus of human Emerin.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens emerin (EMD)|
|EDMD; LEMD5; STA|
Entrez Gene 2010 Human
Entrez Gene 13726 Mouse
Entrez Gene 25437 Rat
|Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family that includes proteins such as LAP2 and MAN1. Each family member, including Emerin, has an ~40 amino acid LEM-domains that binds barrier-to-autointegration (BANF1), a conserved chromatin protein that also serves as a host cell component of retroviral integration complexes, including that of HIV. Emerin is anchored at the inner membrane of the nuclear envelope where it binds to nuclear intermediate filaments that are formed by lamin proteins. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.|
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Western blot analysis of Emerin in human skeletal muscle tissue lysate with Emerin antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of emerin in human muscle tissue with emerin antibody at 2.5 ug/ml.