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Home Antibody All anti-PTGDR2 antibodies

Anti-PTGDR2 Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306387 Rabbit Polyclonal CRTH2 Antibody 100ug $325 In Stock
LC401506 PTGDR2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenCRTH2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human CRTH2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target Nameprostaglandin D2 receptor 2
Alternative NameCD294|CRTH2|DL1R|DP2|GPR44
Database LinkNP_004769
Entrez Gene 11251 Human
Entrez Gene 14764 Mouse
Entrez Gene 309212 Rat
FunctionThe chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
Related PathwayGPCRTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of CRTH2 in Jurkat cell lysate with CRTH2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.
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IHC Image
Immunohistochemistry of CRTH2 in human heart tissue with CRTH2 antibody at 2.5 ug/ml.
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IF Image
Immunofluorescence of CRTH2 in Human Heart tissue with CRTH2 antibody at 20 ug/mL.
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