Home Antibody All anti-STK11 antibodies
Also for STK11 (NM_000455)
|LKB1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human LKB1.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens serine/threonine kinase 11 (STK11)|
|hLKB1; LKB1; PJS|
Entrez Gene 6794 Human
Entrez Gene 20869 Mouse
|The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium. LKB1 often migrates at a higher than expected molecular weight in SDS-PAGE.|
|Protein KinaseDruggable Genome mTOR signaling pathwayAdipocytokine signaling pathway|
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Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 µg/ml in the (A) absence or (B) presence of blocking peptide.