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Home Antibody All anti-STK11 antibodies

Anti-STK11 Antibody

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SKU Description Amount Price Availability*  
TA306371
  • Rabbit Polyclonal LKB1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424705) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenLKB1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human LKB1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens serine/threonine kinase 11 (STK11)
Alternative NamehLKB1; LKB1; PJS
Database LinkNP_000446
FunctionThe LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium. LKB1 often migrates at a higher than expected molecular weight in SDS-PAGE.
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 µg/ml in the (A) absence or (B) presence of blocking peptide.

 

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