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Home Antibody All anti-PDCD4 antibodies

Anti-PDCD4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306366
  • Rabbit Polyclonal PDCD4 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415261) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenPDCD4 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human PDCD4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1
Alternative NameH731
Database LinkNP_055271
Entrez Gene 27250 Human
Entrez Gene 18569 Mouse
Entrez Gene 64031 Rat
FunctionApoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. During this process, the expression patterns of numerous genes are radically altered. One such gene is the programmed cell death protein 4 (PDCD4), whose expression was found to be upregulated in all cell lines following the onset of apoptosis. PDCD4 encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung and prostate. It can bind to and inhibit the helicase activity of the eukaryotic translation initiation factor 4A (4) and inhibit the transactivation and transformation mediated by the transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing the ability of PDCD4 to interfere with the transactivation of AP-1-responsive promoter by c-Jun. There are two known isoforms of PDCD4.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PDCD4 in A-20 cell lysate with PDCD4 antibody at (A) 0.5 and (B) 1ug/ml.
IHC Image
Immunohistochemistry of PDCD4 in mouse brain tissue with PDCD antibody at 2.5 ug/ml.

 

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