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Home Antibody All anti-LIPE antibodies

Anti-LIPE Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306363
  • Rabbit Polyclonal Lipe Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417354) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for LIPE (NM_005357)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLipe antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human lipe.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens lipase, hormone-sensitive (LIPE)
Alternative NameHSL; LHS
Database LinkNP_005348
FunctionAlthough initially described as an adipocyte-specific triacylglycerol lipase, lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that lipe plays a major role in adipocyte proliferation.
Related Pathway
Adipogenesis

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WB Image
Western blot analysis of lipe in human lymph node tissue lysate with lipe antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of lipe in human lymph node tissue with lipe antibody at 2.5 ug/ml.

 

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