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Home Antibody All anti-TNFSF11 antibodies

Anti-TNFSF11 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306362
  • Rabbit Polyclonal sRANK Ligand Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401221) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TNFSF11 (NM_003701)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogensRANK-L antibody was raised against a 14 amino acid peptide from near the center of human sRANK-L .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.25 - 0.5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11), transcript variant 1
Alternative NameCD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TRANCE
Database LinkNP_003692
Entrez Gene 8600 Human
Entrez Gene 21943 Mouse
Entrez Gene 117516 Rat
FunctionThe receptor activator of NF-kappaB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of sRANK-L in rat liver tissue lysate with sRANK-L antibody at (A) 0.25 and (B) 0.5 ug/ml.
IHC Image
Immunohistochemistry of sRANK-L in human liver tissue with sRANK-L antibody at 5 ug/ml.

 

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