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Home Antibody All anti-SNAI2 antibodies

Anti-SNAI2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306361
  • Rabbit Polyclonal Slug Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401070) , 20ug
100ug $325 In Stock
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WB(1)
IF(1)
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Also for SNAI2 (NM_003068)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSlug antibody was raised against a 13 amino acid peptide from near the center of human Slug .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, IF
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens snail family zinc finger 2 (SNAI2)
Alternative NameSLUG; SLUGH1; SNAIL2; WS2D
Database LinkNP_003059
FunctionSlug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
Related Pathway
Adherens junction

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WB Image
Western blot analysis of Slug in 293 cell lysate with Slug antibody at in (A) 0.5, (B) 1 and (C) 2 ug/mL.
IF Image
Immunofluorescence of Slug in human kidney tissue with Slug antibody at 20 ug/mL.

 

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